Heartburn, a common symptom of acid reflux, can be debilitating and disrupt daily life. The burning sensation in the chest and throat can be uncomfortable and painful, often accompanied by a sour taste in the mouth. Fortunately, there are several over-the-counter (OTC) and prescription medications available that can provide quick relief from heartburn. Here, we will explore 10 heartburn medicines that can help alleviate symptoms, along with their mechanisms of action, potential side effects, and recommendations for use.
Understanding Heartburn and Acid Reflux

Before diving into the medications, it’s essential to understand the causes of heartburn and acid reflux. Heartburn occurs when stomach acid flows back up into the esophagus, causing irritation and discomfort. This can happen due to a variety of factors, including a weakened lower esophageal sphincter (LES), hiatus hernia, or eating certain foods that trigger acid production. Understanding the underlying causes of heartburn can help individuals make informed decisions about their treatment options.
1. Tums (Calcium Carbonate)

Tums is an antacid that works by neutralizing stomach acid and providing quick relief from heartburn symptoms. It is available in various flavors and can be taken as needed, usually after meals or at bedtime. Tums is a fast-acting medication that can start to work within minutes, making it an excellent option for those who need immediate relief.
2. Rolaids (Magnesium Hydroxide and Calcium Carbonate)
Rolaids is another antacid that combines the effects of magnesium hydroxide and calcium carbonate to neutralize stomach acid. It comes in a variety of flavors and can be taken as needed to relieve heartburn symptoms. Rolaids is a popular choice among those who suffer from frequent heartburn, as it can provide long-lasting relief.
3. Zantac (Ranitidine)
Zantac is a histamine-2 (H2) blocker that reduces acid production in the stomach. It is available in both OTC and prescription strengths and can be taken before bedtime or as needed to prevent heartburn symptoms. Zantac is a popular choice among those who suffer from frequent heartburn, as it can provide long-lasting relief and prevent future episodes.
4. Pepcid (Famotidine)

Pepcid is another H2 blocker that works by reducing acid production in the stomach. It is available in both OTC and prescription strengths and can be taken before meals or at bedtime to prevent heartburn symptoms. Pepcid is a fast-acting medication that can start to work within hours, making it an excellent option for those who need quick relief.
5. Prilosec (Omeprazole)
Prilosec is a proton pump inhibitor (PPI) that reduces acid production in the stomach by blocking the production of gastric acid. It is available in both OTC and prescription strengths and can be taken before breakfast to prevent heartburn symptoms throughout the day. Prilosec is a popular choice among those who suffer from frequent heartburn, as it can provide long-lasting relief and prevent future episodes.
6. Nexium (Esomeprazole)
Nexium is a PPI that works by reducing acid production in the stomach. It is available by prescription only and can be taken before breakfast to prevent heartburn symptoms throughout the day. Nexium is a fast-acting medication that can start to work within hours, making it an excellent option for those who need quick relief.
7. Prevacid (Lansoprazole)
Prevacid is a PPI that reduces acid production in the stomach. It is available in both OTC and prescription strengths and can be taken before breakfast to prevent heartburn symptoms throughout the day. Prevacid is a popular choice among those who suffer from frequent heartburn, as it can provide long-lasting relief and prevent future episodes.
8. Protonix (Pantoprazole)
Protonix is a PPI that works by reducing acid production in the stomach. It is available by prescription only and can be taken before breakfast to prevent heartburn symptoms throughout the day. Protonix is a fast-acting medication that can start to work within hours, making it an excellent option for those who need quick relief.
9. Dexilant (Dexlansoprazole)
Dexilant is a PPI that reduces acid production in the stomach. It is available by prescription only and can be taken before breakfast to prevent heartburn symptoms throughout the day. Dexilant is a popular choice among those who suffer from frequent heartburn, as it can provide long-lasting relief and prevent future episodes.
10. Aciphex (Rabeprazole)
Aciphex is a PPI that works by reducing acid production in the stomach. It is available by prescription only and can be taken before breakfast to prevent heartburn symptoms throughout the day. Aciphex is a fast-acting medication that can start to work within hours, making it an excellent option for those who need quick relief.
Comparison of Heartburn Medicines
| Medication | Mechanism of Action | Onset of Action | Duration of Action |
|---|---|---|---|
| Tums | Neutralizes stomach acid | Immediate | Short-term |
| Rolaids | Neutralizes stomach acid | Immediate | Short-term |
| Zantac | Reduces acid production | 1-2 hours | Long-term |
| Pepcid | Reduces acid production | 1-2 hours | Long-term |
| Prilosec | Reduces acid production | 1-3 days | Long-term |
| Nexium | Reduces acid production | 1-3 days | Long-term |
| Prevacid | Reduces acid production | 1-3 days | Long-term |
| Protonix | Reduces acid production | 1-3 days | Long-term |
| Dexilant | Reduces acid production | 1-3 days | Long-term |
| Aciphex | Reduces acid production | 1-3 days | Long-term |

FAQ Section
What is the best heartburn medicine for quick relief?
+The best heartburn medicine for quick relief is often an antacid such as Tums or Rolaids, which can provide immediate relief from heartburn symptoms. However, for long-term relief and prevention, H2 blockers or PPIs such as Zantac, Pepcid, or Prilosec may be more effective.
Can I take heartburn medicine with other medications?
+It is essential to consult with your doctor or pharmacist before taking heartburn medicine with other medications, as interactions can occur. Certain medications, such as blood thinners, may interact with heartburn medicines, and your doctor may need to adjust your dosage or recommend alternative treatments.
How long does it take for heartburn medicine to start working?
+The onset of action for heartburn medicine can vary depending on the type of medication. Antacids such as Tums or Rolaids can start working within minutes, while H2 blockers or PPIs may take 1-3 days to start working.
Can I take heartburn medicine during pregnancy or breastfeeding?
+It is essential to consult with your doctor before taking heartburn medicine during pregnancy or breastfeeding, as some medications may not be safe for use during these times. Your doctor may recommend alternative treatments or adjust your dosage to ensure the safety of you and your baby.
What are the potential side effects of heartburn medicine?
+The potential side effects of heartburn medicine can vary depending on the type of medication. Common side effects include headache, dizziness, diarrhea, and constipation. It is essential to consult with your doctor or pharmacist if you experience any side effects, as they may be able to recommend alternative treatments or adjust your dosage.
Natural Remedies for Heartburn Relief
In addition to medication, there are several natural remedies that can help alleviate heartburn symptoms. These include:
- Avoiding trigger foods such as citrus fruits, tomatoes, and chocolate
- Eating smaller, more frequent meals to reduce pressure on the stomach
- Avoiding tight clothing that can put pressure on the stomach
- Raising the head of the bed by 6-8 inches to prevent stomach acid from flowing up into the esophagus
- Losing weight, if necessary, to reduce pressure on the stomach
- Avoiding smoking and nicotine products, which can weaken the LES and exacerbate heartburn symptoms
- Practicing stress-reducing techniques such as meditation or deep breathing exercises, which can help reduce stress and alleviate heartburn symptoms.
By combining these natural remedies with heartburn medicine, individuals can find quick and effective relief from heartburn symptoms and improve their overall quality of life.