What Is Hydrocodone 325 5? Dosage Guide

Hydrocodone ³²⁵⁄₅ is a prescription medication that combines two active ingredients: hydrocodone bitartrate and acetaminophen. This oral tablet is primarily used to treat moderate to moderately severe pain. The “³²⁵⁄₅” notation refers to the dosage of each active ingredient in the medication: 325 milligrams of acetaminophen and 5 milligrams of hydrocodone bitartrate per tablet.

Introduction to Hydrocodone and Acetaminophen

• Hydrocodone Bitartrate: This is an opioid agonist, which means it works by binding to opioid receptors in the brain and spinal cord, altering the perception of and response to pain. Hydrocodone is a semi-synthetic opioid derived from codeine, making it a potent analgesic for pain management.

• Acetaminophen: Known also as paracetamol in many parts of the world, acetaminophen is a non-opioid analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of headaches, other minor aches and pains, and is a major ingredient in numerous cold and flu remedies.

Dosage Guide

The dosage of hydrocodone ³²⁵⁄₅ is dependent on the severity of the pain and the patient’s response to the medication. Since it contains an opioid, there’s a risk of dependence and addiction, so the dosage and duration of treatment should be limited to the minimum required to achieve the desired clinical effect.

• Adult Dosage: typically one tablet (hydrocodone bitartrate 5 mg and acetaminophen 325 mg) every 4 to 6 hours as needed for pain. The maximum dosage is usually 6 tablets (60 mg of hydrocodone bitartrate and 1950 mg of acetaminophen) per day.

• Geriatric Dosage: Older adults may be more sensitive to the effects of this drug, especially the sedative effects. It is advisable to start with a lower dose and monitor closely for side effects.

• Pediatric Dosage: Safety and effectiveness in children have not been established. Use in pediatric patients is not recommended due to the risk of addiction and the potential for fatal respiratory depression, even at recommended doses.

Important Safety Information

• Abuse and Dependence: Hydrocodone ³²⁵⁄₅ contains hydrocodone, an opioid agonist, and is a Schedule III controlled substance. There is a risk of abuse, misuse, and addiction, which can lead to overdose and death. Monitor patients closely for signs of abuse or addiction.

• Respiratory Depression: Risk of respiratory depression increases with the dose. Patients should be instructed to seek medical attention immediately if they experience breathing difficulties.

• Liver Damage: Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product.

Side Effects

Common side effects include lightheadedness, dizziness, sedation, nausea, vomiting, constipation, and abdominal pain. More severe side effects may include respiratory depression, addiction, allergic reactions, and liver failure.

Interactions

Hydrocodone ³²⁵⁄₅ may interact with other medications, including other central nervous system depressants (e.g., benzodiazepines, muscle relaxants), certain antidepressants (e.g., MAOIs), and other opioids, potentially leading to increased sedative effects or other complications.

Conclusion

Hydrocodone ³²⁵⁄₅ is a potent pain reliever but comes with significant risks, especially concerning addiction, overdose, and liver damage. Patients should only use this medication as directed by a healthcare provider, follow dosage instructions carefully, and report any side effects promptly.